Does Testosterone Lower Thyroid Peroxidase Antibodies (TPO)

Does Testosterone Lower Thyroid Peroxidase Antibodies (TPO)

Testosterone is a sex steroid hormone that is secreted by the testes and stimulates the development of sperm, male sex organs and secondary sexual traits. It is also produced by the ovaries in women.

It is said that individuals with exceptionally low levels of testosterone often suffer from autoimmune thyroid diseases such as Hashimoto’s thyroiditis, autoimmune thyroiditis and or Graves disease.

In autoimmune disorders such as Hashimoto’s disease or Graves’ disease, your immune system makes antibodies that mistakenly attack the thyroid gland, and subsequently, cause impaired function of the thyroid.

A Thyroid Peroxidase Antibodies (TPO) test can assist in the diagnosis of Hashimoto or Graves disease and other thyroid diseases. High levels of thyroid peroxidase antibodies or TPO antibodies usually indicate a thyroid autoimmune disorder is present.

So if high levels of TPO antibodies are an indication of thyroid autoimmune disorder, reducing thyroid peroxidase antibodies could indicate a diminution of the seriousness or intensity of the autoimmune disease.

So if men and woman with very low levels of testosterone often suffer from autoimmune thyroid diseases such as Hashimoto’s, does that mean elevating testosterone is the cure?

Can testosterone replacement therapy lower TPO antibodies?

In the image above, a 40 year old male had a total testosterone level of 147 ng/dl, which is considered exceptionally low. Normal testosterone levels are within 264-916 ng/dl.

The image below identifies the same individual’s thyroid peroxidase antibodies score of 89, which is elevated and suggest Hashimoto’s disease.

High Thyroid Peroxidase Antibodies TPO

Testosterone cypionate (Depo-Testosterone) injections were given to raise the individual’s testosterone level for 2 months to see whether or not their TPO antibody levels lower.

The individual’s total testosterone serum was elevated above 1196, which is slightly above normal. See image below.

So does testosterone or TRT lower thyroid peroxidase antibodies? The image below would suggest not. Thyroid peroxidase antibodies only lowered from 89 IU/ml to 86 IU/ml, not significant.

How to Lower Thyroid Peroxidase Antibodies (TPO)

Be sure to bookmark this page and check back soon. We will add selenium and vitamin D3 5000 IU to the diet to see whether or not TPO antibodies lower.